Basic Information
VIS ID
TVIS30016750
Fusion event
HIV-RPS6KA3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
20206997/20188879 (Hg38)
End
20207036/20188879 (Hg38)
Orient
+
Location type
Intronic
Target gene
RPS6KA3
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-1296-5p ; hsa-mir-503-5p ; hsa-mir-320a ; hsa-mir-29a-3p ; hsa-mir-1273e ; hsa-mir-218-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4724-3p ; hsa-mir-636 ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-5696 ; hsa-mir-9-3p ; hsa-mir-4722-5p ; hsa-mir-1253 ; hsa-mir-4729 ; hsa-mir-6165 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-6856-5p ; hsa-mir-5197-3p ; hsa-mir-6758-5p ; hsa-mir-518f-3p ; hsa-mir-518d-3p ; hsa-mir-518c-3p ; hsa-mir-518b ; hsa-mir-518a-3p ; hsa-mir-526b-5p ; hsa-mir-6868-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4524a-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-1911-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-191-5p
Nearest miRNA
hsa-mir-23c/Upstream/171692; hsa-let-7f-2/Downstream/8306676;
Nearest TSS
ENST00000429181/Upstream/16015; ENST00000636971/Downstream/29991;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/46714, chrX-CpG: 197/Downstream/77130
Upstream sequence
AGAATCAAATCACCTGTACTCTTCCCAGCTGCTCTTTCTAATGCCTTTCTGCAGACGTAGTTTGACTAAACCCCCTAGTGCCTGCATTAATAGACAGAGG
Downstream sequence
TCTTGGTTATTTTATTTTGCCtttttttcctttttgtggagaatagggtatcactatgttgcccaggcaggtcttgaactgctgggctcaagctatcttc
Target sequence
GTCCACACATTTAATTCAAAAACATCAGACATGTCATTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate