Basic Information
VIS ID
TVIS30016752
Fusion event
HIV-TAB3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
30868529/30850412 (Hg38)
End
30868386/30850412 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRAXC
Target gene
TAB3
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-195-5p ; hsa-mir-512-5p ; hsa-mir-181a-5p ; hsa-mir-188-5p ; hsa-mir-192-3p ; hsa-mir-5581-3p ; hsa-mir-6872-3p ; hsa-mir-1255b-2-3p ; hsa-mir-4303 ; hsa-mir-3653-3p ; hsa-mir-610 ; hsa-mir-1252-5p ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-342-3p ; hsa-mir-30a-5p ; hsa-mir-892b
Nearest miRNA
hsa-mir-23c/Upstream/1276054; hsa-let-7f-2/Downstream/1733244;
Nearest TSS
ENST00000429181/Upstream/15789; ENST00000445240/Downstream/2475;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/196660, chrX-CpG: 77/Downstream/38372
Upstream sequence
ggttcattatactattttatgtatctttgaaattataataaaagttaaaactaaATTACAGCCCAGGGCAGCAGTTTCACCAACTTCTCTTTTTCCTTTC
Downstream sequence
TCAAGAAGATAGATCGGGggccaggtgcggtggctcatgcctggaatcccagcactttgggaggccgaggcgggcagatcacaaggtcaggagttcgaga
Target sequence
AcatgaactaccaatttctcaatctgggggatggctacatgggggttcattatactattttatgtatctttgaaattataataaaagttaaaactaaATTACAGCCCAGGGCAGCAGTTTCACCAACTTCTCTTTTTCCTTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate