Basic Information
VIS ID
TVIS30016781
Fusion event
HIV-ARHGEF6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135759793/136677634 (Hg38)
End
135759889/136677634 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGEF6
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-877-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1253 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p ; hsa-mir-888-5p ; hsa-mir-371a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/126674; hsa-mir-105-1/Downstream/1990077;
Nearest TSS
ENST00000429181/Upstream/29407; ENST00000478471/Downstream/89709;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/179694, chrX-CpG: 104/Downstream/89237
Upstream sequence
TCCAAGAAATGTGTATACATGGAGCATGGATATTAATTATTAATAGTACCTTAAAAATATAGGAAACAAATCATTTAATTTATTTCACTTAGCCACAGTA
Downstream sequence
TTTAGGGCATTATGACATTTTTATATGTATTTCACACAAGCCTGCTTTTTGAACAAAGTACTTACATGTCAAAATTGCATCTTCATATTTTAGCCACCAA
Target sequence
CTTACACTTGAAAACAAGACAGATATGAAAAACTCTCACATGACAAAAATAACAGGAAAAAACAGAATTTAAAAAAAAACACAGGAAAATGGGCAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate