Basic Information
VIS ID
TVIS30016785
Fusion event
HIV-FMR1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
147016199/147934680 (Hg38)
End
147016255/147934680 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
FMR1
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-129-5p ; hsa-mir-221-3p ; hsa-mir-21-5p ; hsa-mir-130b-3p ; hsa-mir-374a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/649952; hsa-mir-105-1/Downstream/2293324;
Nearest TSS
ENST00000429181/Upstream/4478; ENST00000611273/Downstream/5477;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/21998, chrX-CpG: 21/Downstream/46471
Upstream sequence
TAATGTAGAATTGGATTATTTGCTATTAAATATTAAAAGTAGATTCTACCTGTGGTTACCTGGAAAGAAGAGGATCTCAGAAATAACCAGAAAGACTGCT
Downstream sequence
TTCTGTTTTAGAGATGGTCCACTGCAACACTGGGAACGTTGGAACTTTTCAGAAAGCATTTTTGTGTAAGATTCTGCAAGGCAGATCTTTAGAGAGGTGT
Target sequence
AAAAGTAAATCAGCCTTGTTTTTGTTTTGTTGTTTCTAGTTAGTAAAATGAGATAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate