Basic Information
VIS ID
TVIS30016788
Fusion event
HIV-ARHGAP4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153190624/153925171 (Hg38)
End
153190393/153925171 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
ARHGAP4
Nearest miRNA
hsa-let-7f-2/Upstream/589634; hsa-mir-1184-1/Downstream/55926;
Nearest TSS
ENST00000429181/Upstream/2923; ENST00000438219/Downstream/1073;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/38406, chrX-CpG: 46/Downstream/844
Upstream sequence
CAGCTTCATGGCATTTTGGGGAAGCAGGATGGAGATCATTACCTCCATCTGAGCAAGATGATGGCGAGGCTTGGAAAGCTGGCTCACCCTGTGTAGTCAC
Downstream sequence
CTCAAGCTGGCTCTGGACACAGGCTGCCTTTTCCAAAGGAGGACTGGAGCATACTTTGGTATAAATTGCTTGCACTGAATAATGATGTTAGAACCTACAT
Target sequence
GAAGCTTTTCCAGGGTGTGGGATGCAGACCCAGAGCAAGTGAGGAACCCTTAGACAGTCGTGCTCGAAACCCCAACTTTTCAGTGTGAAATCACTGACCCATATTTGCTGACTGAAGTTTTCCAAGTCTTTCAGCTTCATGGCATTTTGGGGAAGCAGGATGGAGATCATTACCTCCATCTGAGCAAGATGATGGCGAGGCTTGGAAAGCTGGCTCACCCTGTGTAGTCAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate