Basic Information
VIS ID
TVIS30016790
Fusion event
HIV-TKTL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153558489/154330139 (Hg38)
End
153558327/154330139 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
TKTL1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-let-7f-2/Upstream/310150; hsa-mir-1184-1/Downstream/120181;
Nearest TSS
ENST00000429181/Upstream/2763; ENST00000644854/Downstream/4898;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/34317, chrX-CpG: 27/Downstream/2546
Nearest cancer related gene
TKTL1(OG, No orient, 0)
Upstream sequence
GTAATAGTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAAATGTGGATTGAAGTATAGATTCCAGTAGCCTAGTTTCCACAGCACGATAACACCATGAC
Downstream sequence
GCCTACTGCTGTTCCCACCTTGGGATTCTGTGTGCTGCCATCCCACCTGCAGCTGCCCTGGAATTCCCTTCGCTGTTTGCCTTCATCTCCCTCCACGTTT
Target sequence
TAGATAAGTGGTAGAGGTAATCAATTCTTCCGAAGTGTTTCCTTCGTGAATAACTGGTAGAGGTAATAGTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAAATGTGGATTGAAGTATAGATTCCAGTAGCCTAGTTTCCACAGCACGATAACACCATGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate