Basic Information
VIS ID
TVIS42000012
Fusion event
EBV-SDHB integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
132515
Orient
-
Integrated sequence
CCCCTGAGTCACTACCGGTTGGGGTAAGAACTGAGGGGGCAAAGTCATCAATCTCAGCGTAAAAGTTTTCGTGTCTTTCGTTTTCAGGGGACTCATCCTC| |CTGACATTTTCGCCAGCCGCCGGGCGGGCCGGCCTCCTTTCCTGGAAATCCAGCCATGGATCCCACCCGGGGTCTGTGTGCCCTCTCCACACACGACCTG
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
17370955/17044460 (Hg38)
End
17370955/17044460 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
SDHB
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-12136/Upstream/185439; hsa-mir-101-1/Downstream/233429;
Nearest TSS
ENST00000473358/Upstream/21300; ENST00000634972/Downstream/417;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/32373, chr1-CpG: 31/Downstream/9501
Nearest cancer related gene
SDHB(TSG, No orient, 0)
Upstream sequence
tgctgtcatctagtcttttttgtttcacttatagaacacagtagatttagcataattctcaagggccctgggattttcaggatggtaaatgagtattggc
Downstream sequence
TCTGGGGAGGAGGCTTCTGGATGACAGCCTCCCCGCCAGCCTTCCATTCCCTCCTAGGCCTGTTCTCTCCCGGTGGCCCAATCTGACACCAGCTGGTGGC
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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