Basic Information
VIS ID
TVIS42000050
Fusion event
EBV-CCDC186 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
288
Orient
+
Integrated sequence
TCTTGGCAGCAGTGGCCAGCTCATATGCCGCTGCACAAAGGAAACTGCTGACACCGGTGACAGTGCTTACTGCGGTTGTCACTTGTGAGTACACACGCAC| |CATTTACAATGCATGATGTTCGTGAGATTGATCTGTCTCTAACAGTTCACTTCCTCTGCTTTTCTCCTCAGTCTTTGCAATTTGCCTAACATGGAGGATT
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
115897796/114138037 (Hg38)
End
115897796/114138037 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CCDC186
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-2110 ; hsa-mir-25-3p ; hsa-let-7b-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-107/Upstream/359983; hsa-mir-202/Downstream/36068;
Nearest TSS
ENST00000439456/Upstream/5943; ENST00000369280/Downstream/6565;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36703, chr10-CpG: 26/Downstream/35583
Upstream sequence
agagtctctttctgttgcccaggctggagtgcagtgatgcaatcgcagctcacttcaacctccgcctcctgggttcaagcaattctcctgcctcagcctc
Downstream sequence
GGCTATAATGGATATTAATGTTAGGATTTTCtttttgagcacctactacatgccagacacaagataagtattttatattcaccaaccttttaaatctcct
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
Curate