Basic Information
VIS ID
TVIS42000129
Fusion event
EBV-MTCL1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
91692
Orient
+
Integrated sequence
CAGATATGGCACTGCCCGCTTCCGGCTTTGGCAGGAACATACCTTCCCGGCTATCCCTGAGGCCCTTCTTCCTTTTAACGGGAGGAAGAAAGGTGGGCTT| |TGAGGGGTGGGGGAATATGGGTCTCTCATCGCTCTCTTGGTGGACCGCTGCTATCCAAGGCTGTTCAGGTTCCGCCGCGTTGGAAGGACATGGAGTTTGA
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
8762494/8762496 (Hg38)
End
8762494/8762496 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTCL1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-382-5p ; hsa-mir-543
Nearest miRNA
hsa-mir-3976/Upstream/2388071; hsa-mir-1-2/Downstream/1997088;
Nearest TSS
ENST00000575820/Upstream/44598; ENST00000523811/Downstream/19592;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/54937, chr18-CpG: 35/Downstream/21653
Upstream sequence
gttgaactcatataaataaagagtaaaatggtggttaccaggagccgggatgtgagagggagttgaggagatgttggtcaaaggatacaaatttcagtta
Downstream sequence
TCAAATGAACAGTCGGGGTGATGGAGTCTTCCTTGGCCATGGAGAAGAATGGATAGAAAAGATGCTGTCCCACAGAAGGCAGTTTCCTACGTGGAGTGAG
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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