Basic Information
VIS ID
TVIS42000140
Fusion event
EBV-MED25 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
145755
Orient
+
Integrated sequence
GAGTGGGGGATGCTAGCCAATTTAGCTTCCCCTCCCCTTAACAGGGGGTCTCGCGGGGTGCCAATTGTCGCCTGCCTTCCCCCGCTTCCCCTTGTTAACT| |TATAGCATGATAGGTAGGTCACCTAACGTGGAAGCCTGGTGGGTGATCCTTCCTCGGTAGGGAGCGCTTAGGGCTGTTGAGCTCAACAGCCCCACCTGGG
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50330381/49827124 (Hg38)
End
50330381/49827124 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
MED25
miRNAs that regulate target gene
hsa-mir-21-3p ; hsa-mir-324-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10395/Upstream/35190; hsa-let-7e/Downstream/4894;
Nearest TSS
ENST00000633603/Upstream/8782; ENST00000599722/Downstream/3719;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8619, chr19-CpG: 191/Downstream/23409
Upstream sequence
gttgatccattcaattgttgatggacacttgggttgtttccaccttttggctgttgtgcagaaccgtgccatgaccatgggtatgcaaatttcttttgga
Downstream sequence
AGACCCTCAGAGGGGTGCTCGGTCTCCACACACGTCCCCTGCAGCAAAGGTCAGCCTCTCACGACCACGTGACCGGAATAATGGTGGCAACCACAGCTGC
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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