Basic Information
VIS ID
TVIS42000153
Fusion event
EBV-COA5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
109365
Orient
-
Integrated sequence
TTGATAAATCTGATAAATGACCTCTTGCATGGCCTCTTGTAAAGCGCAGTGTAGGATGGGTAGATGGGGTCAAATTCTGACTTGGAAAAGAGGTACTTGA| |AGCGGCACTTAATCTCATAAATGCAGCTCCGGTCGGTGAACAGTATAAAGTCTCCCTGTGACTCCACATTGACGCAAAGATCCAGAGACACCCCAAAAAT
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99220692/98604229 (Hg38)
End
99220692/98604229 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
COA5
miRNAs that regulate target gene
hsa-mir-450b-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-548aw ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-6871-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1805876; hsa-mir-10b/Downstream/2705221;
Nearest TSS
ENST00000437798/Upstream/32332; ENST00000466492/Downstream/561;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/158844, chr2-CpG: 84/Downstream/3952
Upstream sequence
gtgtgtgtatgtgtgtgtgtgtTCTATATTTTCTATTTTTTTAAACATATCAAGGAGCAGAAGTATCCTGTGCTTTTCTTTTAGGGAATCATGGTTTCAC
Downstream sequence
ATTTTCTCACAAAGTACAAAATAATTGTCCTTCTGAAAATAGTCCTTTTTAAAAGTGTTAAAGGAGGAAAATAGAAAGTTATGTAGGAAATAGTTCTTAA
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
Curate