VISDB Viral Integration Site DataBase

VIS ID

TVIS42000187

Fusion event

EBV-EWSR1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Nasopharyngeal carcinoma (NPC)

Quality evaluation

Normal

Reported year

2005

PubMed ID

Virus name

EBV

Reference genome

Start

48676

Orient

+

Integrated sequence

CGTGTCTGCTGAACGTGCCTGCCGCGGGTCCCCGGGCCTACAAGTGTTTCAGATCCCACGCCTCCAGACCGGTGTCTGGCCCGGATTACCCTCCCTTGGC| |CGTGTTTTGCATGGACTGCGGTTACTGCTTGAACTTTGGAAAGCAGACAGGTGTAGGAGGCAGGCTCAATTCCTTTAGACCCACTCTCCAGTTTTATCCC

Chromosome

chr22

Cytoband

q12.2

Reference genome

Start

End

29669660/29273671 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7a-5p ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-362-5p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-23b-3p ; hsa-mir-196a-5p ; hsa-mir-100-5p ; hsa-let-7c-5p

Nearest miRNA

hsa-mir-1286/Upstream/813723; hsa-let-7a-3/Downstream/733378;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/4757, chr22-CpG: 164/Downstream/32661

Nearest cancer related gene

EWSR1(OG, No orient, 0)

Upstream sequence

AACATTCATGATACTGTGATTAtttgtcttgttttgttgtttttgttttgttttTTTAATCTTCTAGAAAGGAATGTTTTTGATTTTGGTTCTCCAATTT

Downstream sequence

AGTCCATTTTATTGCTAAAATACAAAAGTTCATGTATGAAGTTCTTGCATTCGTTTTTTTTTGGAGCAGGCATATGGGCAACAAAGCTATGGAACCTATG