Basic Information
VIS ID
TVIS42000201
Fusion event
EBV-DAG1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
116241
Orient
-
Integrated sequence
ATAACAGGGCCCCGTAGACAGTCTTTTGTGAGTAAATAGAGATGATGACATGGATGTAGAGACTGAGGACCACATCCACCACCTTCTCGGAGGAGGCCCC| |CCTAAACAGCATCAGGCAGCAAGGGAACACAAAGGAAACCAGGGCCGGGATGTGAGGCCTCAGCGCCCCCTCCTGATCAAAGAGGGCCTCGCTGACCCCG
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
49572640/49535207 (Hg38)
End
49572640/49535207 (Hg38)
Orient
+
Location type
Intronic
Target gene
DAG1
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-mir-1229-3p ; hsa-mir-423-5p ; hsa-mir-18a-3p ; hsa-mir-222-3p ; hsa-mir-3676-3p ; hsa-mir-142-3p
Nearest miRNA
hsa-mir-12127/Upstream/261021; hsa-let-7g/Downstream/270930;
Nearest TSS
ENST00000440867/Upstream/24983; ENST00000467456/Downstream/19133;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/64350, chr3-CpG: 39/Downstream/4607
Upstream sequence
ggagcattgttgtcagaatttagtaagaattcatataaaagactgagctcagtgcctggaatatagtatgtttttttaaataaataataataaatattAC
Downstream sequence
GTGAGATTATTTCTGATGACCTCATCAAAAAATAAACAATTCCCAATGTTCCAGGTGAGGGCTTTGAAAGGCCTTCCAAACAGCTCCGTCGCCCCTAGCA
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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