Basic Information
VIS ID
TVIS42000273
Fusion event
EBV-EYS integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
148361
Orient
-
Integrated sequence
GCTTGGGAATGCTCTTAGGGCCTGGAAGCTTGTCATTGGATTCATCGTTTCCTGAACTACAGGCGTAGGGCCTATTGTAGCAGGCATGTCTTCATTCCTG| |CGTACCGAATGGCATGAAGGCACAGCCTGTTACCATTGGCACCTTTTTTCCATGTAAACCTCCGTGATCCTGGGTCCTTTGGAGACTCAAGTGTGAATTT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65784895/65075002 (Hg38)
End
65784895/65075002 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/7684790; hsa-mir-10524/Downstream/6301958;
Nearest TSS
ENST00000381078/Upstream/361667; ENST00000449928/Downstream/227935;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1438442, chr6-CpG: 22/Downstream/226358
Upstream sequence
GAACGCCGCGTCTcgccgcccgcgggcccgccgggAGACTGCGGGTCCGTCTCGCGGGTGGGGCGCCCCGGTCCCTCTCGTTTCCTGGAGGCCACAGGTC
Downstream sequence
GTAGTCATTGTGTATAATACTGAAAATCACTACTTAATAAAATGTATATAATTTTCATATCATGTTGTGAGTTCTCACCCACTCTACTTGTTATCTTCAG
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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