VISDB Viral Integration Site DataBase

VIS ID

TVIS42000282

Fusion event

EBV-PTPRK integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Nasopharyngeal carcinoma (NPC)

Quality evaluation

Normal

Reported year

2005

PubMed ID

Virus name

EBV

Reference genome

Start

72384

Orient

-

Integrated sequence

CCGGTTTGCTCAAACGTGACATGGAGAAACTGGGGGAATTTGTCTTCTGGCACAGCTGTTGCCAGGGTGCTCATGAGCGAGGGCCAGATGCAGGAGCTGA| |CCCAGGCGACGAGATCCAGGCCCAGATGTCCCTCTATCATGGCGCAGACATTCTCCACGGTGGGGGGCAGGGTCTCGCGGGTCCTCTGGATTAGATAGTC

Chromosome

chr6

Cytoband

q22.33

Reference genome

Start

End

128508449/128187304 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-133b ; hsa-mir-9-5p ; hsa-mir-935 ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-218-5p ; hsa-mir-1283 ; hsa-mir-7849-3p ; hsa-mir-548c-3p

Nearest miRNA

hsa-mir-10398/Upstream/1702591; hsa-mir-1202/Downstream/3604868;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/670743, chr6-CpG: 173/Downstream/331709

Nearest cancer related gene

PTPRK(TSG, No orient, 0)

Upstream sequence

tcaggagtcaaaaacgtgttccatgggctaaactaacatcaaggtgccagcagagctgtgtttcttttgaaagctctaaggaagaattagtttccttgct

Downstream sequence

AACATTAATTCCAACATTTCTATCTTTAAGGAAGTGATATATAAAAGAAAACAAAAATTTGTAGTCTGGAAACCTAATATGAAAAAAATGCTTAcacatt