Basic Information
VIS ID
TVIS42000297
Fusion event
EBV-MAGI2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
Nasopharyngeal carcinoma (NPC)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
70913
Orient
+
Integrated sequence
CTCGCGTGTTAGGAAGGAAGCAGGGTGCCAGCTCTTTGAGCTTGGTCAGGATCACCTTGCTAAGACTCATGGCGCAGGCCAGGAGGATGTCTTCCGCGGG| |AGCTAGGGGCAGGTCGCCGTGGTAGGTGATCTCCTGGAGCCAAAAGATGGTCTCTTCTAGCATGGCCACCAGGGTGCAGAGCCCCGCGTTCTGGATCGCC
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
78475145/78845829 (Hg38)
End
78475145/78845829 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAGI2
miRNAs that regulate target gene
hsa-mir-655-3p ; hsa-mir-487b-3p ; hsa-mir-134-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-3944-5p ; hsa-mir-5690 ; hsa-mir-4660 ; hsa-mir-4704-5p ; hsa-mir-3912-5p ; hsa-mir-487a-3p
Nearest miRNA
hsa-mir-10525/Upstream/2930560; hsa-mir-10399/Downstream/13358186;
Nearest TSS
ENST00000635602/Upstream/74506; ENST00000428298/Downstream/94021;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/805089, chr7-CpG: 26/Downstream/606420
Upstream sequence
aaaaaaaaaaaaaaaaaaGTCAAAAATGTTAAGGGTGCAGGTGTGTCCACTTTGCTGTTTCAGCTACACACAGCACACATCACACAAGGTTAAATGAACA
Downstream sequence
ATTTAAGCTGACATTTAAGAACAGATTGGGTCAGAGGGGAGAGTGACATCATTTGCAGGTGTACAGTAGGGCAACGTGAAAAAGGAGATGTGGAAAGATA
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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