Basic Information
VIS ID
TVIS42000431
Fusion event
EBV-MGMT integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Cell line
Disease
B-cell lymphoma (BL)
Quality evaluation
Normal
Reported year
2005
PubMed ID
15681063
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
168272
Orient
+
Integrated sequence
TCCACTCACGAGCAGGTGGTGTCTGCCCTCGTTGGAGTTAGAGTCAGATTCATGGCCAGAATCATCGGTAGCTTGTTGAGGGTGCGGGAGGGAGTCATCG| |TGGTGGTGTTCATCACTGTGTCGTTGTCCATGGTAATACATCCAGATTAAAATCGCCAGAAACAGGAGGAGCCAAAGGAGATCAACCAATAGAGTCCACC
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
131508796/129710532 (Hg38)
End
131508796/129710532 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MGMT
miRNAs that regulate target gene
hsa-mir-181d-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-648 ; hsa-mir-767-3p ; hsa-mir-370-3p ; hsa-mir-661 ; hsa-mir-409-3p ; hsa-mir-124-3p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-107/Upstream/3890710; hsa-mir-202/Downstream/132767;
Nearest TSS
ENST00000439456/Upstream/8415; ENST00000428273/Downstream/58312;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/243086, chr10-CpG: 25/Downstream/68654
Upstream sequence
ccacctaggcctcccaaagtgtttgaattacaggcatgagccacagtgccggccTCTGCAGAAATACttatttccgtatctcagataatgaaattgagac
Downstream sequence
aagaagaggtttggagacctgctcgatgtcaggtgggcagttactgaaggacttgagtctgcaaccaggtctcctaaagtcaaggtcagatccccttccc
Reference
Takakuwa, T., et al. Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4). Virus Res,2005, 108(1-2): 133-138.
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