VISDB Viral Integration Site DataBase

VIS ID

TVIS42000653

Fusion event

EBV-PPARA integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

B-cell lymphoma (BL)

Quality evaluation

Normal

Reported year

2005

PubMed ID

Virus name

EBV

Reference genome

Start

2543

Orient

+

Integrated sequence

GCGCTGCGAGACACTTACTCGGGCCACTTGGTCCTTCAGCCCACGGAGACCCTTGACACATGGAAGGTGTTGAGCAGGGACACACGAACCGCTCATAGTT| |TGGAGCACGGATTCATTCATGCCGCGGGGACCATCCAGGCCAACTGCCCACAGCTGTTTATGAGACGCCAGCACCCCGGCCTCTTTCCCTTCGTTAATGC

Chromosome

chr22

Cytoband

q13.31

Reference genome

Start

End

46618346/46222449 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-519d-3p ; hsa-mir-22-3p ; hsa-mir-10b-5p ; hsa-mir-21-5p ; hsa-mir-141-3p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-9-5p ; hsa-mir-548d-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-519c-3p ; hsa-mir-33a-5p ; hsa-mir-130a-3p ; hsa-mir-27a-5p ; hsa-mir-4699-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-5006-5p ; hsa-mir-30c-1-3p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6797-5p ; hsa-mir-4755-3p ; hsa-mir-1249-5p ; hsa-mir-4459 ; hsa-mir-6757-5p ; hsa-mir-4779 ; hsa-mir-6089 ; hsa-mir-129-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-4753-3p ; hsa-mir-3671 ; hsa-mir-130b-5p ; hsa-mir-5692a ; hsa-mir-34a-5p ; hsa-mir-9-3p ; hsa-mir-130b-3p ; hsa-mir-196b-5p

Nearest miRNA

hsa-let-7a-3/Upstream/108681; hsa-mir-12114/Downstream/2051915;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/7557, chr22-CpG: 130/Downstream/27418

Nearest cancer related gene

PPARA(TSG, No orient, 0)

Upstream sequence

ACAGGTTTAATTTGTATTAAATAGCTTGAAGCAATCCTTATTGGGAATTACAAGGTGGAATTTTAGTCACAGGAAAATAAAGCATTTCACAAGCTACTTA

Downstream sequence

CTTTCATGAACAAACCAAACCTCTTCTTTACTGAGTCCTTTAATTCTTCAGTGAATTCTCCAATTAAATAGGCCGAGACATTTTAGAAGTTTCCAGCAGA