Basic Information
VIS ID
TVIS42001111
Fusion event
EBV-chr9:p24.1 integration
Validated
No
Detection method
GenCap Enrichment+NGS
Data source
Curated
Sample type
Tumor
Disease
NK/T cell lymphoma (NKL)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25355872
Virus Sequence
Virus name
EBV
Reference genome
NC007605
Start
61270
Orient
-
Integrated sequence
ACATAGGCCGGATCCGCGCGCGCCGTTTGGCCGGCCCTCAGGGACCGGCAGTATGCCTCGACGTCTGTCCGCGGGGCCGCCGCCACCGCTGCCGTCCACT| |GCCTTCTTCCCTGCTCGCCGGGGAGTAGGGGGGGCTTACAGGGGAGGGCCGGAGCCGGGGCCGGGGCCTGCCACAGGCGGCTGTAGCGGACCCATAGCAG
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5331916/5331916 (Hg38)
End
5331916/5331916 (Hg38)
Orient
-
Location type
Intronic
Target gene
RLN1 ; RLN2
miRNAs that regulate target gene
hsa-mir-4453 ; hsa-mir-4538 ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-548n ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6505-5p ; hsa-mir-7156-3p ; hsa-mir-4789-5p ; hsa-mir-7153-3p ; hsa-mir-8084 ; hsa-mir-6509-5p ; hsa-mir-4795-3p ; hsa-mir-3924 ; hsa-mir-331-5p ; hsa-mir-4742-3p ; hsa-mir-1183 ; hsa-mir-1258
Nearest miRNA
hsa-mir-101-2/Upstream/481541; hsa-let-7a-1/Downstream/675910;
Nearest TSS
ENST00000422679/Upstream/26947; ENST00000474218/Downstream/7480;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/27440, chr9-CpG: 45/Downstream/7110
Upstream sequence
TTGTACGGTACCATAAATACTTGACCACCTGTAGTACATAAAAACCCAACCCACATCAAACCCCCCCCCCCCATGCTTACAAGCAAGTACAGCAATCAAC
Downstream sequence
tagtttcagtagtagagatggggtttcactgtgttagccaggatggtctcgatctcctgacctcatgatctacctgccttggcctcccaagagtgTGATT
Reference
Cao, S., et al.High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project. J Virol,2015, 89(1): 713-729.
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