VISDB Viral Integration Site DataBase

VIS ID

TVIS42001112

Fusion event

EBV-PRKN integration

Validated

No

Detection method

GenCap Enrichment+NGS

Data source

Curated

Sample type

Disease

Nasopharyngeal carcinoma (NPC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

EBV

Reference genome

Start

98992

Orient

-

Integrated sequence

GCGCCTCTTGTCGGACGAGGAGGAAGAGACTTCACAGAGCAGCAGCTACACTCTGGGGTCTCAGGCCTCCCAGTCTATCCAGGAGGAGGACGTGAGTGAC| |ACTGATGAGTCTGACTACTCAGATGAAGACGAGGAGATTGATTTGGAGGAAGAGTACCCCAGTGACGAAGACCCATCTGAGGGCAGTGATAGCGACCCCT

Chromosome

chr6

Cytoband

q26

Reference genome

Start

End

162053279/161632247 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3187-3p ; hsa-mir-1303 ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-483-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-10398/Upstream/2867494; hsa-mir-1913/Downstream/4877107;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/639715, chr6-CpG: 76/Downstream/13638

Nearest cancer related gene

PRKN(TSG, No orient, 0)

Upstream sequence

TGCTGTATTTATAGGGAGGGCAGAGAGGATTTCCCTACACAATCTAGCTGAAAGTTCTCACATGCAATCATATCATTGCATTTGCTTTTCTAGGCATTTC

Downstream sequence

CTAAGGTTACAAAAGCTGTGGTAAGAATCGTCCTTAATTGCAAGGGTTATTCTAGGATTTACATGAGAAAAAAAACCCCATAAATGGCAACCCAGGCAGA