VISDB Viral Integration Site DataBase

VIS ID

TVIS42001113

Fusion event

EBV-PRKN integration

Validated

Yes

Detection method

Sanger sequencing

Data source

Curated

Sample type

Disease

Nasopharyngeal carcinoma (NPC)

Quality evaluation

Perfect

Reported year

2015

PubMed ID

Virus name

EBV

Reference genome

Start

84585

Orient

-

Integrated sequence

GGCCCCCACAGTGGTCCTCCAGCGACCACCCACGCAGCAAGAGCCTGGCCCCGTCGGCCCACTGAGTGTCCAGGCTCGGCTGGAGCCATGGCAACCTTTG| |CCTGGGCCCCAAGTGACAGCAGTTCTACTTCACGAAGAATCCATGCAGGGTGTCCAAGTACATGGTTCGATGCTAGACCTTCTTGAAAAAGACGATGAAG

Chromosome

chr6

Cytoband

q26

Reference genome

Start

End

162314936/161893904 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3187-3p ; hsa-mir-1303 ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-483-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-10398/Upstream/3129151; hsa-mir-1913/Downstream/4615450;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/247247, chr6-CpG: 75/Downstream/833440

Nearest cancer related gene

PRKN(TSG, No orient, 0)

Downstream sequence

CTCTCCACTGCCAAACATTTTGGCACACGATTTGTCACAAAGAAGAACACA

Junction sequence