Basic Information
VIS ID
TVIS43000039
Fusion event
MCV-OFCC1 integration
Validated
Yes
Detection method
RACE
Data source
Curated
Sample type
Tumor
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23085629
Virus Sequence
Virus name
MCV
Reference genome
EU375803
Start
1836
Integrated sequence
TTATTGTTTATAACTTTATCAAAGCATAGAGTATTTGCTATTAAGAATTTTTGCTCTACCTTCTGCACTATAAGCTTTTTAATTTGTAAAGGAGTGAATA| |AGATGCCTGAAATGTATAATAATTTATGCAAGCCCCCTTACAAATTACTGCAAGAGAATAAGCCACTGCTCAATTATGAATTTCAAGAAAAAGAAAAAGA
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37.p5
Start
9842760/9842527 (Hg38)
End
9842760/9842527 (Hg38)
Location type
Intron6
Target gene
OFCC1
miRNAs that regulate target gene
hsa-mir-181a-5p
Nearest miRNA
hsa-mir-3691/Upstream/3673092; hsa-mir-10398/Downstream/597190;
Nearest TSS
ENST00000381078/Upstream/680750; ENST00000645232/Downstream/561975;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/443161, chr6-CpG: 35/Downstream/476921
Upstream sequence
TATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATAGAGAGAGAGAGACCTGCTAAAGTTTCTCTAAAGAGTCCTACAGGAGAA
Downstream sequence
TCCTGCTGCTCCCTTTGAGTCATTAGTTACTTCTGTGAGGGTACCAAGCTGGGCTGCACTGTCCTTTTTACAAATATTTAGGTCTGCAATGAATGGTTGA
Target sequence
AAAGCACAGCAGGCAGCTGGGTCAATACAATTGATCTCATCGTTTAACATTTTGCATCAGAGAAAAAGTCAGTGGCAAGAGCCTCACCTTCCAGCGGGG
Reference
Guastafierro, A., et al. Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods,2013,187(1): 6-14.
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