Basic Information
VIS ID
TVIS43000040
Fusion event
MCV-chr3:q26.33 integration
Validated
Yes
Detection method
RACE
Data source
Curated
Sample type
Tumor
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23085629
Virus Sequence
Virus name
MCV
Reference genome
EU375803
Start
596
Integrated sequence
CTAGATTTTGCAGAGGTCCTGGGTGCATGCTTAAGCAACTTAGAGATTCTAAGTGCGCTTGTATTAGCTGTAAGTTGTCTCGCCAGCATTGTAGTCTAAA| |AACTTTAAAGCAAAAAAACTGTCTGACGTGGGGAGAGTGTTTTTGCTATCAGTGCTTTATTCTTTGGTTTGGATTTCCTCCTACTTGGGAAAGTTTTGAC
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37.p5
Start
88824524/88775374 (Hg38)
End
88824524/88775374 (Hg38)
Location type
Non-coding region
Nearest miRNA
hsa-let-7g/Upstream/1549097; hsa-mir-12124/Downstream/7584590;
Nearest TSS
ENST00000440867/Upstream/436851; ENST00000452448/Downstream/332150;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/625011, chr3-CpG: 41/Downstream/339111
Upstream sequence
ACTATATTAGCATCAGGTGTTATCCAGTGCAGCTGTGGTGGTCATGAGAGTGCTTGAATCACACCTCCCTAACTTCAGGCAGCTCAGCACAAAGACAGAC
Downstream sequence
ACAAGTGTGCAAGAGTCACAGCGTTAGTGGGTTTGGGGTACCCACTAATGCAGATAAGGATGCAGTGAACAAAGACTTATATTACAACACTTAATTCCCT
Target sequence
TTTGCTTGGGGGAAAGTAAGAGAAAACAAAAAGAGACCCTGTGTGGTAATCTAGGGAATCCTCCTGGACCTTACCGAAGACCACCAAAGCAGTACCTCT
Reference
Guastafierro, A., et al. Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods,2013,187(1): 6-14.
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