Basic Information
VIS ID
TVIS43000041
Fusion event
MCV-chr10:q23.1 integration
Validated
Yes
Detection method
RACE
Data source
Curated
Sample type
Tumor
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23085629
Virus Sequence
Virus name
MCV
Reference genome
EU375803
Start
491
Integrated sequence
TCCACAAGCTCAGAAGTGACTTCTCTATGTTTGATGAGGTTAGTACAAAATTTCCTTGGGAAGAATATGGAACTTTAAAGGATTATATGCAAAGTGGATA| |TAATGCTAGATTTTGCAGAGGTCCTGGGTGCATGCTTAAGCAACTTAGAGATTCTAAGTGCGCTTGTATTAGCTGTAAGTTGTCTCGCCAGCATTGTAGT
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37.p5
Start
36041150/35752222 (Hg38)
End
36041150/35752222 (Hg38)
Location type
Unidentified ORF
Nearest miRNA
hsa-mir-1265/Upstream/110970; hsa-mir-107/Downstream/7245341;
Nearest TSS
ENST00000439456/Upstream/109944; ENST00000626667/Downstream/26080;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/109257, chr10-CpG: 21/Downstream/12972
Upstream sequence
CAGGCATGCAGTGCATAGTAATCAGAGAAGACCTCAATGCCCCACTTTCAGCATTGGGAAAACCGTCCAGACAGAAAATCAACAAGAAAACATTGGACTT
Downstream sequence
CTTTTTTTTTTGAGACGAAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCACGATCTCCGCTCACTGCAAGCTCTGCCTCCTGGGCTCACACCAGT
Target sequence
AATCTGCACTGTAGACCAAATGGATCATTCCACACTGGTAACATTTTCTAGTTTAGCAGTTTGCTGTAGTCTTTTTCGAAGGCTACGAAGCATAAGTAA
Reference
Guastafierro, A., et al. Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods,2013,187(1): 6-14.
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