Basic Information
VIS ID
TVIS43000045
Fusion event
MCV-PTP4A2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28049147
Virus Sequence
Virus name
MCV
Reference genome
HM355825.1
Host Sequence
Chromosome
chr1
Cytoband
p35.2
Reference genome
GRCh37/hg19
Start
31940936/31468089 (Hg38)
End
31941056/31468209 (Hg38)
Location type
Intronic
Target gene
PTP4A2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-145-5p ; hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-1296-5p ; hsa-mir-320b ; hsa-mir-877-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-106b-5p ; hsa-mir-320a ; hsa-mir-183-5p ; hsa-mir-92a-3p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-mir-6776-3p ; hsa-mir-3065-5p ; hsa-mir-619-3p ; hsa-mir-875-3p ; hsa-mir-6887-3p ; hsa-mir-218-5p ; hsa-mir-580-3p ; hsa-mir-6770-5p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-5197-3p ; hsa-mir-483-3p ; hsa-mir-382-5p ; hsa-mir-495-5p ; hsa-mir-6124 ; hsa-mir-190a-3p ; hsa-mir-6765-3p ; hsa-mir-5011-5p ; hsa-mir-656-3p ; hsa-mir-1277-5p ; hsa-mir-6890-3p ; hsa-mir-34c-3p ; hsa-mir-3074-3p ; hsa-mir-3148 ; hsa-mir-362-3p ; hsa-mir-4640-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-3529-3p ; hsa-mir-8064 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-12136/Upstream/728857; hsa-mir-101-1/Downstream/290451;
Nearest TSS
ENST00000473358/Upstream/54276; ENST00000466998/Downstream/107364;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/53926, chr1-CpG: 37/Downstream/118661
Nearest cancer related gene
PTP4A2(OG, No orient, 0)
Upstream sequence
gagggaggaaggagggaggaaagagggaggaagaggaaggaaggagggaggaaggagggaggaagaggaaggaaggagggaggaaggagggaggaagagg
Downstream sequence
gatgtttttgctttgttttgtttttgagacagagtcttgctctgtcgcgcaggctggagtgcagtggcgtgatcttggttcactgcaagctctgcctccc
Target sequence
caggttgtcagtggcctctgtgcttttgggtatttctaaggctatgcccttgtttacactgacaaaaagatggaatggctgcttaaggagggtaaagctaggatggggcagttactaata
Reference
Starrett, G. J., et al. Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. MBio,2017, 8(1).
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