Basic Information
VIS ID
TVIS43000047
Fusion event
MCV-CBFA2T2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28049147
Virus Sequence
Virus name
MCV
Reference genome
HM355825.1
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
32132694/33544888 (Hg38)
End
32132694/33544888 (Hg38)
Location type
Intronic
Target gene
CBFA2T2
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-7977 ; hsa-mir-7160-5p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-1273g-3p ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3202 ; hsa-mir-3714 ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4257 ; hsa-mir-4533 ; hsa-mir-455-3p ; hsa-mir-490-3p ; hsa-mir-5694 ; hsa-mir-605-3p ; hsa-mir-6086 ; hsa-mir-619-3p ; hsa-mir-6499-3p ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6807-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1307041; hsa-mir-1-1/Downstream/504231;
Nearest TSS
ENST00000382410/Upstream/54771; ENST00000344201/Downstream/17446;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/54225, chr20-CpG: 17/Downstream/99476
Upstream sequence
ctctgtttgattctactttctccccatcaatggtctttccctccctccctccccactttgcattaccccctccccgacacacacacataaacatccacac
Downstream sequence
gcatctgatagatgcacaataaatatttgttgcatgcatgagtgaatagaatagaacagaatagaatagaatagaatagaatagaatagaatagaataga
Reference
Starrett, G. J., et al. Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. MBio,2017, 8(1).
Curate