VISDB Viral Integration Site DataBase

VIS ID

TVIS43000053

Fusion event

MCV-CASZ1 integration

Validated

Yes

Detection method

DIPS-PCR

Data source

Curated

Sample type

Disease

Merkel cell carcinoma (MCC)

Quality evaluation

Normal

Reported year

2019

PubMed ID

Virus name

MCV

Reference genome

Start

5043

End

1529

Integrated sequence

AAGCTAAAAAACAACAGAGAAACTCCTGTTCCTACTAATTTTCCTATTGATGTTTCTGATTATCTTAGCCATGCTGTATATAGTAATAAAACAGTAAGTTGTTTTGCCATTTATACTACTTCTGATAAAGCTATAGAGTTATATGATAAGATTGAGAAATTTAAAGTTGATTTTAAAAGCAGGCATGCCTGTGAATTAGGATGTATTTTATTGTTTATAACTTTATCAAAGCATAGAGTATTTGCTATTAAGAAT

Chromosome

chr1

Cytoband

p36.22

Reference genome

Start

End

10790267 (Hg38)

Location type

Intron1

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-151a-5p ; hsa-mir-4665-3p ; hsa-mir-486-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-885-3p ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-3195 ; hsa-mir-3648 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-1908-3p ; hsa-mir-6784-5p ; hsa-mir-7975 ; hsa-mir-4540 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4670-3p ; hsa-mir-648 ; hsa-mir-6838-3p ; hsa-mir-4517 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-8068 ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-33a-3p

Nearest miRNA

hsa-mir-12136/Upstream/822809; hsa-mir-101-1/Downstream/1238891;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/85399, chr1-CpG: 244/Downstream/3570

Upstream sequence

GGACTTTTTAATTTCAAAATAAGAAAGCCAGTAGAAAGTGGACAGAGAAGAAACCAACACGGGGTGCTGGCAATGATGCTTCCAGCCTGCACCCTCCCAA

Downstream sequence

CCACGCCACGTATCCCGGGCACAGGGACCGGCCTTATCGGTCTGCCGGGCTGCCCTTCAGAGAAAGGGAAGAACAGATCCTAATGAAATTACGGTTTTTA