Basic Information
VIS ID
TVIS43000055
Fusion event
MCV-LUZP2 integration
Validated
Yes
Detection method
DIPS-PCR
Data source
Curated
Sample type
Cell line
Disease
Merkel cell carcinoma (MCC)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30873613
Virus Sequence
Virus name
MCV
Reference genome
EU375803
Start
4991
End
4880
Integrated sequence
CTTGGTTAACCAAAGAAGCCACTAATGAGAAATTTGAAAACTGTTCAGCTGTGAACCCAAGTTGAGCTAAAGCCTCAATGCCAGAAATACCCTCAATTGTCATTAAACTGGA
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh38
Start
25063435 (Hg38)
End
25063435 (Hg38)
Location type
Intron10
Target gene
LUZP2
miRNAs that regulate target gene
hsa-mir-653-5p ; hsa-mir-5585-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-205-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-652-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548s ; hsa-mir-3165 ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-7162-3p ; hsa-mir-6078 ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-340-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p
Nearest miRNA
hsa-mir-210/Upstream/1644245; hsa-let-7a-2/Downstream/2451535;
Nearest TSS
ENST00000527297/Upstream/171670; ENST00000533942/Downstream/671335;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/566243, chr11-CpG: 29/Downstream/1268555
Upstream sequence
ccagctgatattgagggatgtctgTACACTGAATTGTGAAAATATTTAAAGCCATTTATCCATCTTAATACAATATTTTCCAAAATATCTGTGTGAATAT
Downstream sequence
ATCTTCACACCAGCATTGTAAAAGACAGAAAGGGAAAGAGAAGAGAGAGGAGTCTGCTTCAGCATGTTATAGCCAACAGTAAATGTATAGTTTTTGTTTA
Reference
Schrama, D., et al. Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration. Int J Cancer,2019
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