VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000015

Fusion event

HTLV-1-PAQR8 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

p12.2

Reference genome

GRCh37/hg19

Start

52258692/52393894 (Hg38)

End

52258692/52393894 (Hg38)

Orient

+

Location type

Intronic

Target gene

PAQR8

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-326 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-3679-3p ; hsa-mir-6881-3p ; hsa-mir-877-3p ; hsa-mir-361-3p ; hsa-mir-5196-3p ; hsa-mir-129-5p ; hsa-mir-136-5p ; hsa-mir-153-5p ; hsa-mir-192-3p ; hsa-mir-4480 ; hsa-mir-4776-3p ; hsa-mir-7705

Nearest miRNA

hsa-mir-10398/Upstream/244853; hsa-mir-10524/Downstream/883099;

Nearest TSS

ENST00000381078/Upstream/31448; ENST00000635843/Downstream/19120;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/30686, chr6-CpG: 20/Downstream/9289

Upstream sequence

taaggaaagtcctataatgaaggactttaagtgcagtggcagttaggtgaaggagcacctgaggggaagccttcacagggaccatttgagatgggacatg

Downstream sequence

aagcatgagtaggagttggccagtggacatcagtggtgtgggcattccaggcaTGCATAGAAGCACAAAGTCCTGAGAGGATGGCAGAATAACTGGAACA

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.