Basic Information
VIS ID
TVIS44000022
Fusion event
HTLV-1-DHCR7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71157335/71446289 (Hg38)
End
71157335/71446289 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
DHCR7
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-1260b ; hsa-mir-218-5p ; hsa-mir-374b-3p ; hsa-mir-7156-3p ; hsa-mir-4766-3p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-7-5p ; hsa-mir-6853-5p ; hsa-mir-451b
Nearest miRNA
hsa-mir-10392/Upstream/573921; hsa-let-7a-2/Downstream/27214;
Nearest TSS
ENST00000527297/Upstream/4942; ENST00000529369/Downstream/1789;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10473, chr11-CpG: 78/Downstream/1679
Upstream sequence
atatatgtgacagctcggttagagcatccagaaaaaaatgaatgagagatgcatagaaaccttaccaaatgaaaaaaaaaaaaaaaaaaaaaggaaggca
Downstream sequence
actgttaactccaggaaaaataaaaagtcatataaggaaggaaaaaaagaaaccaagccattattataggaccttacttggctcaacagtgaataatggt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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