Basic Information
VIS ID
TVIS44000031
Fusion event
HTLV-1-TNS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
47608814/47569216 (Hg38)
End
47608814/47569216 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNS3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-let-7i-5p ; hsa-mir-8070 ; hsa-mir-5003-5p ; hsa-mir-8485 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-1178-3p ; hsa-mir-6071 ; hsa-mir-6749-3p ; hsa-mir-377-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-5088-3p
Nearest miRNA
hsa-mir-1183/Upstream/2687416; hsa-mir-10399/Downstream/9386569;
Nearest TSS
ENST00000635602/Upstream/29615; ENST00000429010/Downstream/12415;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/31604, chr7-CpG: 75/Downstream/12298
Upstream sequence
GTCCCCGATGCAGTATTTGTGAACACGATCTGGGGGTCTCAGCACAAAGCAAAAAGGGGGAGAGGAGACATTTTCCCAGGACAAGTCTGCTGGATGCCCA
Downstream sequence
ACATCTTTATAAGAACAAAACCTGCATTTAAATATTACACAAGGGTccaggcgcagtggctcacgcctgtaatccgagcactttgggaggccgaggaggg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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