Basic Information
VIS ID
TVIS44000040
Fusion event
HTLV-1-HERC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
89407044/88485893 (Hg38)
End
89407044/88485893 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
HERC5
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-3529-3p
Nearest miRNA
hsa-mir-12113/Upstream/1185310; hsa-mir-1243/Downstream/10511494;
Nearest TSS
ENST00000502981/Upstream/12880; ENST00000597259/Downstream/35896;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/28096, chr4-CpG: 69/Downstream/37363
Upstream sequence
ATGAAGAACTGGACCCCAGAGTACTTTGGGATATTGCATTGTTTTTTTTTTTCTTCCTATTGAAAGTTCTTTAAAAATTTCCTATGAATTAAAAATAACT
Downstream sequence
AGAGGTTTATCATTACATCATCAATCTCTACTCTTAAATCTTAGATATTCTTTATGTTCATGAAAATTTGGGGCTCTGGCAGTGGAGGAATTGGATAGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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