Basic Information
VIS ID
TVIS44000049
Fusion event
HTLV-1-BBS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66301052/66533581 (Hg38)
End
66301052/66533581 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA11H
Target gene
BBS1
miRNAs that regulate target gene
hsa-mir-1229-5p ; hsa-mir-203b-3p ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-5002-3p ; hsa-mir-6861-5p ; hsa-mir-3692-5p
Nearest miRNA
hsa-mir-10392/Upstream/884328; hsa-let-7a-2/Downstream/400853;
Nearest TSS
ENST00000527297/Upstream/10099; ENST00000511191/Downstream/12425;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/52829, chr11-CpG: 72/Downstream/12117
Upstream sequence
accctcccccatccctagttattaggttaaaaaatactcagattactatttctattactatgtgaaagttaactgcggagccaagagttggactataatt
Downstream sequence
aaattaccttccttgtactttctttttaatggagttaatgagttgccctgagtttctcatttactttgttttctgatggactgattgctaattcttcccc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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