Basic Information
VIS ID
TVIS44000067
Fusion event
HTLV-1-CRTC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18804995/18694185 (Hg38)
End
18804995/18694185 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
CRTC1
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-4638-3p ; hsa-mir-4787-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-4696 ; hsa-mir-520f-5p ; hsa-mir-3675-3p ; hsa-mir-451b ; hsa-mir-3667-5p ; hsa-mir-3120-3p ; hsa-mir-7111-3p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-324-5p ; hsa-mir-6134 ; hsa-mir-6845-3p ; hsa-mir-6769b-3p ; hsa-mir-3183 ; hsa-mir-4723-3p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-1470
Nearest miRNA
hsa-mir-10395/Upstream/307551; hsa-let-7e/Downstream/740878;
Nearest TSS
ENST00000633603/Upstream/10507; ENST00000601916/Downstream/41424;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/10336, chr19-CpG: 17/Downstream/6566
Nearest cancer related gene
CRTC1(OG, No orient, 0)
Upstream sequence
tgcaccactgcactccccagcctgggtaacagagcgagactccgtctcagaaaaaaaaaaaaaaaaaTAGGCTggcatggtggctcatgcctgtggtccc
Downstream sequence
agctacttgggaggctgaggcgagaggttcccttgagcctaggagcttgaggctgcagtgaactatgatcacgccacttcactccagcctggccgacaga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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