Basic Information
VIS ID
TVIS44000077
Fusion event
HTLV-1-LRBA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
151317742/150396590 (Hg38)
End
151317742/150396590 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRBA
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-769-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-12113/Upstream/2613922; hsa-mir-1305/Downstream/2092737;
Nearest TSS
ENST00000502981/Upstream/80956; ENST00000507934/Downstream/182499;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/317036, chr4-CpG: 62/Downstream/183021
Upstream sequence
cacacacacacacacacacGTactcccagaaataatgtttatcacttatcctggcatccctcaacccactcaagctggcatataaaattaaccatAATAG
Downstream sequence
TAGTCTACAGGGAAAAGCTATTGAGGGAAAATTCTTTTCAATCACTCTAGAGAATCAACTAGTAGTAGAATACGAATGTATTGGTTTATTTACTAATTAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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