Basic Information
VIS ID
TVIS44000079
Fusion event
HTLV-1-SV2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
75528846/76233021 (Hg38)
End
75528846/76233021 (Hg38)
Orient
-
Location type
Intronic
Target gene
SV2C
miRNAs that regulate target gene
hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-517-5p ; hsa-mir-520g-5p ; hsa-mir-3613-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-10397/Upstream/3354358; hsa-mir-103a-1/Downstream/6607134;
Nearest TSS
ENST00000502646/Upstream/148835; ENST00000506257/Downstream/58744;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/58673, chr5-CpG: 133/Downstream/169913
Upstream sequence
gctcttttttggttccatatgaactttcaagtagttttttccaattctgtgaagaaagtcattggtagcttgatggggatggcattgaatctgtaaatta
Downstream sequence
ccttgggcagtatggcctttttcacgatattgattcttcctacccatgagcatggaatgttcttccatttgtttgtatcctcttttattttgttgagcag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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