Basic Information
VIS ID
TVIS44000080
Fusion event
HTLV-1-RIOK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
96507097/97171393 (Hg38)
End
96507097/97171393 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA5B
Target gene
RIOK2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-101-3p ; hsa-let-7b-5p ; hsa-mir-484 ; hsa-mir-10a-5p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-10397/Upstream/1092181; hsa-mir-103a-1/Downstream/3645089;
Nearest TSS
ENST00000502646/Upstream/3674; ENST00000504012/Downstream/11767;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/234972, chr5-CpG: 18/Downstream/12322
Upstream sequence
CATTAAAATCTCCATGAATCAGCCCATGATTTGCAAGTTTGACAATTAGTTCCATAGCTTCATCATATACTGATGCAGGATCTTCAACATGGTGTATCTG
Downstream sequence
ACATCTGAAAGTATTTTAAGCATGAAAATAGGTTACTTGTGTTCATTTACGGTTTTAACGAAAGTATGTATGCATGTGAACATATATATTATTTCCATGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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