Basic Information
VIS ID
TVIS44000097
Fusion event
HTLV-1-FRMD4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
13799355/13757355 (Hg38)
End
13799355/13757355 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMD4A
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-218-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-3155a/Upstream/1032002; hsa-mir-107/Downstream/625845;
Nearest TSS
ENST00000439456/Upstream/27972; ENST00000446193/Downstream/215014;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/99815, chr10-CpG: 86/Downstream/134127
Upstream sequence
GTCGACAGACATGAGGTTTTTTGTTTTACATGTATATACATCAGGAAATGAAATGAGATTACTACATGCTGTGCTAAGGAAAACAATAAAAGTGAAAAAA
Downstream sequence
TGTTATTTTTAGATAAGACTATTTCCTAAACCTTTAGAAGTATCGTACAAATTTGTCCTCCATTTGGTAGAATATGAACATGTGTGGTCTGTATCTCTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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