Basic Information
VIS ID
TVIS44000117
Fusion event
HTLV-1-USP37 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
219376172/218511449 (Hg38)
End
219376172/218511449 (Hg38)
Orient
+
Location type
Intronic
Target gene
USP37
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-30c-5p ; hsa-let-7e-5p ; hsa-mir-4487 ; hsa-mir-8060 ; hsa-mir-302b-5p ; hsa-mir-302d-5p ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-4501 ; hsa-mir-185-3p ; hsa-mir-4709-3p ; hsa-mir-3591-5p ; hsa-mir-616-3p ; hsa-mir-3119 ; hsa-mir-5580-5p ; hsa-mir-215-3p ; hsa-mir-4280 ; hsa-mir-142-3p ; hsa-mir-6832-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-4775 ; hsa-mir-130b-5p ; hsa-mir-5003-3p ; hsa-mir-32-3p ; hsa-mir-606 ; hsa-mir-6894-3p ; hsa-mir-19a-3p ; hsa-mir-4763-5p ; hsa-mir-6828-5p ; hsa-mir-891a-5p ; hsa-mir-4772-3p ; hsa-mir-4264 ; hsa-mir-1910-5p ; hsa-mir-455-3p ; hsa-mir-191-5p ; hsa-mir-548av-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10b/Upstream/108727; hsa-mir-1244-1/Downstream/311641;
Nearest TSS
ENST00000437798/Upstream/13036; ENST00000489687/Downstream/2979;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/104703, chr2-CpG: 106/Downstream/56595
Upstream sequence
ccaagctggtgtgcaatggcgcaatctcggctcactgcaacctccgcctcccggattcaagcgattctcctgcctcaggctcccgactagctgggactac
Downstream sequence
aggcgtgcgccaccacacctggcttactttttgtatttttagtagaaacggggtttcaccatgttagccaggctggtctcgaactcctgacctcaggtga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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