Basic Information
VIS ID
TVIS44000120
Fusion event
HTLV-1-TTLL9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
30461781/31873978 (Hg38)
End
30461781/31873978 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTLL9
miRNAs that regulate target gene
hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6722-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4533 ; hsa-mir-9500 ; hsa-mir-6888-5p ; hsa-mir-552-3p ; hsa-mir-4428
Nearest miRNA
hsa-mir-103a-2/Upstream/266738; hsa-mir-1-1/Downstream/363817;
Nearest TSS
ENST00000382410/Upstream/2851; ENST00000619753/Downstream/5828;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/3069, chr20-CpG: 38/Downstream/5763
Upstream sequence
agaaagagaaagaaaACACTGATAAACGAGCCTGAAGACTAGCTCCTTACCATGGCCCTGGCCTTAGCAGCTCTGCGATCCTAGGCGGGTGAGCCAATGT
Downstream sequence
CCCTTAATTTACCCATAGAGGGGCAATTGTAACAGTCCTTTGTGTTCCCACTGAGTGCTAAGGGGAAAGATACAAATTACATGTAGGAAAGAATTCTTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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