Basic Information
VIS ID
TVIS44000135
Fusion event
HTLV-1-GMDS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
2069082/2068848 (Hg38)
End
2069082/2068848 (Hg38)
Orient
+
Location type
Intronic
Target gene
GMDS
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-302c-5p ; hsa-mir-1231 ; hsa-mir-4423-3p ; hsa-mir-3143 ; hsa-mir-496 ; hsa-mir-3622b-5p ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-6868-5p ; hsa-mir-3128 ; hsa-mir-654-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-4803 ; hsa-mir-3196 ; hsa-mir-6816-5p ; hsa-mir-3180-3p ; hsa-mir-6787-5p ; hsa-mir-3180 ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-744-5p ; hsa-mir-6812-3p ; hsa-mir-1307-3p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-6720/Upstream/678437; hsa-mir-10398/Downstream/785183;
Nearest TSS
ENST00000381078/Upstream/25415; ENST00000530833/Downstream/107143;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/443615, chr6-CpG: 106/Downstream/176036
Upstream sequence
gctcaaggaaataaaagaggatacaaacaaatggaagaacattccatgctcatgggtaggaagaatcaatatcgtgaaaatggccatactgcccaaggta
Downstream sequence
atttacagattcaatgccatccccatcaagctaccaatgactctcttcacagaaatggaaaaaactgctttaaagttcatatggaaccaaaaaacagcct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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