Basic Information
VIS ID
TVIS44000136
Fusion event
HTLV-1-EYS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65403691/64693798 (Hg38)
End
65403691/64693798 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/7303586; hsa-mir-10524/Downstream/6683162;
Nearest TSS
ENST00000381078/Upstream/316003; ENST00000449928/Downstream/19537;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1057238, chr6-CpG: 22/Downstream/607562
Upstream sequence
cttgagggttgggaacgttcttaggtcacaaatagcgtagccattaatttttttaaaaaatcaataaagaaggctttataaaaattaagatactctcttc
Downstream sequence
attaaaaatggaagttaaaaaaataagacttagatgggggagaagtagcctccaaacatacatcaaactaaagaattatactcatacatatatTTGTTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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