Basic Information
VIS ID
TVIS44000137
Fusion event
HTLV-1-SLC35F1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
118369964/118048801 (Hg38)
End
118369964/118048801 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC35F1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-1257 ; hsa-mir-3650 ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-4790-3p ; hsa-mir-4649-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929
Nearest miRNA
hsa-mir-10398/Upstream/11264581; hsa-mir-1202/Downstream/1020246;
Nearest TSS
ENST00000381078/Upstream/141275; ENST00000621341/Downstream/105641;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/128395, chr6-CpG: 121/Downstream/601698
Upstream sequence
agaaataaaagaggatacaaacaaatggaagaacattccatgctcatgagtaggaagaatcaatatcgtgaaaatggccatactgcccaaggcaatttat
Downstream sequence
agattcaatgccatccccatcaagctaccaatgtctttcttcacagaattggaaaaaactactttaaagttcatatggaaccaaaaaagagcccgcatcg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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