VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000144

Fusion event

HTLV-1-ADAMTSL1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

p22.1

Reference genome

GRCh37/hg19

Start

18616371/18616373 (Hg38)

End

18616371/18616373 (Hg38)

Orient

+

Location type

Intronic

Target gene

ADAMTSL1

miRNAs that regulate target gene

hsa-mir-132-3p ; hsa-mir-25-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4533 ; hsa-mir-6079 ; hsa-mir-6086 ; hsa-mir-6133 ; hsa-mir-6134 ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p

Nearest miRNA

hsa-mir-101-2/Upstream/42994; hsa-let-7a-1/Downstream/1794775;

Nearest TSS

ENST00000422679/Upstream/142140; ENST00000546040/Downstream/41242;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/177569, chr9-CpG: 79/Downstream/160387

Upstream sequence

cttggcctcccaaagtgttgggattacaggcataagccaccacacccagcataaaatttgcttttatcaaatgtcccctgaccattaggcttcatcagag

Downstream sequence

gttattagagccacctctttgaaactgcttgtatgtatttgctcagatgttattgggacattgttatatgacattgtctttcagaagactcacAATTAAT

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.