Basic Information
VIS ID
TVIS44000149
Fusion event
HTLV-1-LCORL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18011789/18010166 (Hg38)
End
18011789/18010166 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LCORL
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-6839-3p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-1273e
Nearest miRNA
hsa-mir-12113/Upstream/4382209; hsa-mir-12115/Downstream/2518109;
Nearest TSS
ENST00000502981/Upstream/48134; ENST00000511431/Downstream/10568;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/198562, chr4-CpG: 178/Downstream/10646
Upstream sequence
ACCTATAATCAGAGCTAATTAAAACAACAATCTATTTGTCAGAGTACCTGCTTTTTTTCCATGTAAACAGTGCTCTATTCTTTTACACTAATTCCTTCTA
Downstream sequence
AGTTTAAAAAGTTAATTGAAAATTATAATACAGAAGAGAGCACTGGGTTTCCTTCTAACCAAACATGCATTTTACTTAAGTATCTTACATAGGCCTGTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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