Basic Information
VIS ID
TVIS44000171
Fusion event
HTLV-1-DACH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72415347/71841215 (Hg38)
End
72415347/71841215 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DACH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-217
Nearest miRNA
hsa-mir-1297/Upstream/5622891; hsa-mir-1267/Downstream/5856797;
Nearest TSS
ENST00000623511/Upstream/826074; ENST00000618209/Downstream/25554;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1733128, chr13-CpG: 62/Downstream/24015
Nearest cancer related gene
DACH1(TSG, No orient, 0)
Upstream sequence
AGATTTCAACTCTAAAAAGTTTATAAATATTAAACCACTTTATTTGCTATCTTCTAAACCTGCCTTTCATCTGATGCAATATTTTCTTCCCAGGGTTTCT
Downstream sequence
AACAGCATTAATATAAAATTTAATACGTATATGTGCTGTGAGGCAACTCAAAAGAGAACTTTAAAAAATAATTATGTCTTTTCTCTTTTTTTTTGCTTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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