Basic Information
VIS ID
TVIS44000174
Fusion event
HTLV-1-OSTF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77758272/75143356 (Hg38)
End
77758272/75143356 (Hg38)
Orient
-
Location type
Intronic
Target gene
OSTF1
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-4735-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p ; hsa-mir-6844 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6749-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-7108-3p ; hsa-mir-4258 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-1273f ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-136-5p ; hsa-mir-143-3p ; hsa-mir-3120-5p ; hsa-mir-3198 ; hsa-mir-325 ; hsa-mir-3685 ; hsa-mir-384 ; hsa-mir-411-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4317 ; hsa-mir-4534 ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-5571-3p ; hsa-mir-6088 ; hsa-mir-6514-5p ; hsa-mir-6832-5p ; hsa-mir-6888-3p ; hsa-mir-7975 ; hsa-mir-8055 ; hsa-mir-8082
Nearest miRNA
hsa-mir-101-2/Upstream/4333272; hsa-let-7a-1/Downstream/8826392;
Nearest TSS
ENST00000422679/Upstream/54813; ENST00000455583/Downstream/436313;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/54453, chr9-CpG: 148/Downstream/746958
Upstream sequence
AATTCACATTTTGCAGTTACTATGGAAGATAACTAGGATATAGGGCTGGGGGTTATACTCGAGTTGAGCCCtttaacatttttttccaacttttaaaaat
Downstream sequence
ttgtgtataatttacattaagtaagtacataaatcttaagcatacagcttgattaattttttttacacctgttcaccacaacccagatgaagctagagaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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