VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000182

Fusion event

HTLV-1-PARD3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr10

Cytoband

p11.22

Reference genome

GRCh37/hg19

Start

34412948/34124020 (Hg38)

End

34412948/34124020 (Hg38)

Orient

Location type

Intronic

Target gene

PARD3

miRNAs that regulate target gene

hsa-mir-483-3p ; hsa-mir-93-3p ; hsa-mir-766-3p ; hsa-mir-218-5p ; hsa-mir-4503 ; hsa-mir-6839-3p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6792-5p ; hsa-mir-629-5p ; hsa-mir-3194-3p ; hsa-mir-7158-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-660-3p ; hsa-mir-6796-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-2861 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-661 ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-4438 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-1261 ; hsa-mir-129-5p ; hsa-mir-3201 ; hsa-mir-4791 ; hsa-mir-5004-3p ; hsa-mir-7850-5p ; hsa-mir-8068

Nearest miRNA

hsa-mir-1265/Upstream/3755355; hsa-mir-107/Downstream/955578;

Nearest TSS

ENST00000439456/Upstream/214782; ENST00000446211/Downstream/212300;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/786751, chr10-CpG: 188/Downstream/690176

Upstream sequence

CTTTGACAGCTTAATATGCGAGTGTGCTGCCACTTATGAAATAAAATCATTGTTATATTAACATATACATAGAATATTCAATAATTTCAAATAATCTATC

Downstream sequence

ACTTTTCTTCTTATAGATAAGGAAAATAGTGTGTAAGTATGTGTGGGTGTGCACGTGTATATATATATCCACACACATATGTAATATTTTTATAAAGGAT

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.