Basic Information
VIS ID
TVIS44000184
Fusion event
HTLV-1-TCF12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
57584725/57292527 (Hg38)
End
57584725/57292527 (Hg38)
Orient
-
Location type
Intronic
Target gene
TCF12
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-1224-3p ; hsa-mir-548v ; hsa-mir-33a-3p ; hsa-mir-139-5p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10393/Upstream/1919493; hsa-mir-11181/Downstream/1878656;
Nearest TSS
ENST00000557528/Upstream/10072; ENST00000620766/Downstream/7838;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/372720, chr15-CpG: 58/Downstream/13813
Nearby gene
TCF12(+3995) ;
Upstream sequence
aaaatgaaattaatttcaaatacaattacaaaagtcatacaaaattgttatagcaaaactaaattgctgtttaatgtggaacttgagcatattttaatgt
Downstream sequence
atttgatcttattaaatttggtatagaaggaatgtaccttaacacaataaagaagcatctatgacaaacccatagctaacatcctaactcactggtgaaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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