Basic Information
VIS ID
TVIS44000191
Fusion event
HTLV-1-AP1S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100804272/101160991 (Hg38)
End
100804272/101160991 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA7F
Target gene
AP1S1
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-1-3p ; hsa-mir-4796-3p ; hsa-mir-4276 ; hsa-mir-7847-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-6124 ; hsa-mir-194-3p ; hsa-mir-6783-5p ; hsa-mir-5693 ; hsa-mir-4500 ; hsa-let-7a-5p ; hsa-let-7f-5p ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-let-7g-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-4524a-3p ; hsa-mir-4781-3p ; hsa-mir-1304-3p ; hsa-mir-1182 ; hsa-mir-4524b-3p ; hsa-mir-3689d ; hsa-mir-4278 ; hsa-mir-4716-3p ; hsa-mir-6732-5p ; hsa-mir-6752-5p ; hsa-mir-6794-5p ; hsa-mir-6805-5p ; hsa-mir-6842-5p ; hsa-mir-6851-5p ; hsa-mir-7110-5p ; hsa-mir-129-5p ; hsa-mir-3672 ; hsa-mir-6864-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-10525/Upstream/1436; hsa-mir-10399/Downstream/1132112;
Nearest TSS
ENST00000635602/Upstream/4317; ENST00000461205/Downstream/4123;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/5793, chr7-CpG: 255/Downstream/1992
Upstream sequence
ATATAAATATGTCAGGTTAAAGGGAAAAGGTGTTCAGGGCACTTCTTGTCCTCTCTGTCCCATAACCTACCTCCACCCTCCCCCTAGCCAGCCAGGCAGC
Downstream sequence
TTCTCTGCCTGGGAGGGGAGCCTGGACCCCCCTCTTTCTCCTTGGCTGCAGTGGGGCCTTTATCCAGTGCCAGGGAGGAACAACATAGTTAATTTTTTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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